Cognitive Enhancement Stacks
Kicking off the week, he posted a 'heavy' Day 1 stack: 40mg fasoracetam, 150mg bromantane, 250mg bemethyl, 75mg armodafinil, 3mg pinealon, plus magnesium l-threonate, l-tyrosine, citicoline, NMN, and P5P, calling it 'not even an exaggeration' [1]. He added sodium butyrate to the mix for maximum memory retention, calling it a 'natural hdac inhibitor' that opens up chromatin where plasticity genes are located, recommending 2g timed right around learning [2]. For bromantane specifically, he recommended dosing early AM with fatty food, at least 1g of l-tyrosine, 4mg P5P, 250mg citicoline, and 200mg UMP for the advanced version [3]. When a follower reported no effects from 50mg bromantane after a week, he told them to up the dose to 75mg and ensure at least 2g of l-tyrosine daily [3]. He posted a photo of '100mg bromantane 150mg armodafinil' claiming it shows what the combo 'will do to a motherfucker' [4], and later declared that 'modafinil + bromantane + vitamin E + coca cola + a fucked up diet' has him moving like a young Donald Trump, calling the stack 'the equivalent of a biological diplomatic status' [5]. For a follower experimenting with bromantane, he suggested upping l-tyrosine to 3g split into two doses (75mg early morning, 75mg with lunch) if sleep isn't an issue [6]. He also confirmed that adding 5-10mg tropisetron with bromantane is 'highly synergistic' for attention and working-memory support, raising the 'quality of thoughts' [7]. For travel, he recommended a 'modafinil + epitalon circadian reset' when landing in a new timezone, explaining the modafinil helps him stay awake until local night so he can sleep at the right time [8]. In his detailed Q4 scheduling thread, he outlined his morning routine: wake at 8:30am, drink orange juice, take his daily stack, brush teeth, make the bed, and dress in 'real clothes, preferably drippy as fuck.' He stressed never scrolling in the mornings and getting the most dopamine from work [9].
Peptides & Bioregulators
Pinealon was the standout peptide of the week. He called it his favorite Khavinson bioregulator, claiming it 'evaporates brainfog within like 2 doses' and deepens REM and restorative sleep [10]. He said it's cut his need for sleep from 7.5 hours to around 6 hours by making sleep more efficient [11]. He resurfaced his February article on Pinealon, noting it 'enters the nucleus and binds directly to DNA' to tell genes to express protective proteins, and calling it 'genetic rewriting' with effects that persist for weeks after stopping [11], [12]. He also claimed he hasn't gotten a headache during an active Pinealon cycle, suggesting it targets the root cellular triggers of headaches [13]. For dosing, he takes 2-3mg almost every morning, preferring the acute cognitive benefits over nighttime dosing which some find sedating [10], [11]. He recommended cycling 1 month on, 2-3 months off, noting the effects 'STAY after you pause dosing' [11]. He also said Pinealon + magnesium l-threonate might cut true sleep need from 7-8 hours to 5-6 hours for months, and that it pairs well with stims [14]. On Vilon, he recommended a protocol of '30 on, 30 off' but said he'll probably do '60 on, 30 off' in the winter, dosing 3-4mg in the morning or pre-workout [15]. For Epitalon, he posted a side-by-side comparison of waking up normally vs. after a week of 6mg daily epitalon [16]. He also wrote a deep dive on Epitalon's neuroprotective properties, explaining how it stops lipid peroxidation chain reactions in the brain at a thousand times lower dose than the raw pineal extract it came from [17].
Pharmacology & Compound Deep-Dives
His noopept deep-dive was a standout: he called it 'a delivery vehicle, and nothing more,' explaining the parent molecule has a brain half-life of 5-10 minutes and is undetectable after an hour. The real active compound is cycloprolylglycine (CPG), an endogenous dipeptide your own tissue makes, associated with AMPA modulation and raised BDNF and NGF in the hippocampus [18]. He stressed it's not a 'raises acetylcholine' drug as often repeated, and needs 6-8 weeks at 10-20mg sublingual twice daily to show memory formation benefits [18]. He defended modafinil against amphetamines, stating that looking at any timespan longer than 3 years, 'modafinil mogs. it mogs hard as fuck.' He's read 'hundreds of horror stories about adderall and vyvanse. zero about modafinil' [19]. When pushed back, he argued the disagreement stems from writing to different audiences—he aims for people who want to win without making biohacking their whole life [19]. He explained why modafinil 'stops working' for most people: it's rarely receptor-level tolerance, but rather counteracting sleep circuits (GABAergic parafacial zone neurons) becoming overwhelmingly strong and suppressing the wake-promoting effects [20]. For those who feel wired and useless instead of focused, he recommended 400mg l-theanine, 5g taurine, magnesium glycinate, and low caffeine to 'absorb the noradrenergic overshoot' [21]. On modafinil analogues, he said he's tried all of them and none compare to pharmaceutical modafinil/armodafinil. Flmodafinil did nothing, didesoxymodafinil was underwhelming, and adrafinil/fladrafinil are 'plainly inferior.' 'Modvigil and waklert will always have my heart' [22]. He resurfaced his July article on Vitamin E, arguing that the real problem isn't synthetic vs. natural, but megadosing isolated alpha-tocopherol, which displaces the other 7 protective compounds (4 tocopherols + 4 tocotrienols). 'When you megadose isolated alpha, you're not just displacing gamma-tocopherol. You're crowding out the entire tocotrienol family too' [5]. He noted that 99% of the time people report modafinil stopped working, it's still working but they miss the initial euphoria. 'It's not meant to be a rush through your body. It's smooth. Subtle. But highly effective. You just have to direct it' [23]. On 9-Me-BC, he clarified it isn't boosting dopamine the way most think—the benefits come mostly from downstream MAOi effects, and the direct dopamine boost shown in cell studies happens at much higher doses than people use [24]. He shared his experience with beta blockers, specifically nebivolol at 5mg, saying it 'added a lot of calm i didn't know i didn't have' and slowed his heartrate, recommending it for those running heavy stimulants [25]. He also corrected that nebivolol doesn't drop melatonin production like bisoprolol does [25]. He argued that high performers operate on the verge of chaos where most nootropics can push the system over the edge, so their stacks should focus on mitochondrial or global system support rather than receptor or neurotransmitter boosting. 'Maxed out mitochondrias is the advanced, yet overlooked thing you want as a high performer' [26].
Mindset, Discipline & Entrepreneurship
The Q4 sprint was the biggest mindset theme. He posted a detailed thread on preparing for Q4, calling for 'three months, one room, one goal' and a meticulously planned day repeated over and over. The plan covers biology optimization, habits and routines, accountability, milestone motivation, daily writing, and not missing a single day. 'Build systems that protect you from yourself and make it impossible to fail' [27], [28]. He wrote that the curse of discipline is that every day looks the same, while the curse of indiscipline is that every year looks the same [29]. He stressed always doing something with intention and avoiding the middle and half-assing. 'If you're working, work. Phone in another room, headphones on, doing one thing at a time' [30]. He argued that stress and anxiety is a sign your nervous system is unregulated, but if you're a man in the 21st century trying to find your place in the arena, it's also a sign you're 'doing exactly what you should be doing.' If your stomach doesn't feel twisted by an iron fist sometimes, you're probably not challenging yourself enough [31]. On entrepreneurship, he posted that if someone calls themselves an 'entrepreneur' you just know they're broke. 'The answer is always i'm a janitor' [32]. When challenged on lying, he explained it's to protect yourself from people who want to network or pick your brain [32]. He wrote a longer reflection on the big leagues, noting that 99% of people are not fit to run a business, and 99% of the remaining 1% should scale to a comfy spot and enjoy the ride. The few remaining will 'live their life as synonymous with their work and fistfight to death' [33]. He told @thealexwalton that the hunger is 'insatiable and innate' and he can't help himself from building a cage. 'Skin in the game is like oxygen... comfort is boring. Having fun gets old a lot faster than striving does' [33]. He declared he'll never sell courses because he 'deeply despises gurus' and bioenhancement is too individual for a course. Instead, he offers $2k end-to-end 1-on-1 consulting [34]. He wrote that having good and bad days is normal and 'there is nothing wrong with you' [35], and that in life you'll either get everything you ever wanted or you won't, and if you don't, 'you never really wanted it anyways' [36]. He also said you can't be a trailblazer and be anal about everything being backed by hundreds of western placebo-controlled studies. 'We are on the frontier mister, load your fucking gun and start shooting' [37].
Sourcing & Logistics
He provided specific sourcing links for oral BPC-157, recommending Your Protocol for the US (with code BASED for 10% off) and Mandimart for EU/UK [38], [39]. He noted the EU and UK distributor may still have the old 500mcg version [39]. When asked about COAs, he said you can email them for it and they'll match it to the right batch, noting they have a 'very solid reputation' [39]. For Pinealon, he provided US and EU/UK sourcing links via Your Protocol and Mandimart, with the BASED discount code. He noted the oral pill version was sold out for 2 months and just came back [11]. He also shared a science.bio link for subcutaneous Pinealon in the US [11]. When asked about a cheaper brand (Vita Stream) offering 10mg pills, he said 'that's simply too much' [11]. He announced that a US sourcing solution for 'Pushpa' (Indian supplier) is being tested, quoting his August post calling for freight forwarding help in Northern Ireland. 'Patience will be rewarded. No corners cut' [40]. For bromantane, he restocked EU bromantane via euro-nootropics.com with discount code 'based7', noting the 'basedbiohacker effect' of buying everything they had [3]. When asked about India sources, he said he doesn't have one [41]. When someone asked about finding bromantane in Vietnam, he asked them to share with the community [1]. He asked his audience for a warm intro to someone at 8sleep, offering a financial reward for a connection [42].
other
He spent several posts venting about copycat accounts stealing his style and content, calling it 'pathetic and embarrassing' and asking followers to comment a specific photo under any impersonator [43], [44]. He also reported an imposter account [45]. He posted a list of his favorite movies and shows including The Godfather, Drive, Heat, and True Detective S1, asking followers to bombard their brains with examples of behavior they want to train [46], [47]. When asked for a rom-com recommendation, he suggested 'Crazy Stupid Love' [48]. He posted about tanning testicles for higher testosterone, saying 'socrates did it' and 'if there is will, there is way' [49]. He said DSIP 'just doesnt do shit' [50], and joked about neuralinks when asked if a video was AI [51]. He also joked that someone asking about an 8-month-old on a flight should 'let the baby nibble some cypro' [52]. He complained about a content creator with metaglasses getting in his face in Washington Square Park, calling it 'the lowest tier human character that exists right now. absolute scum' [53].
Also this week
Injury, Gut-Brain Axis & BPC-157 (~9%): BPC-157 was a major focus, especially the oral form which he said 'just came back after disappearing for weeks.' He listed its benefits including reversing dopamine receptor desensitization from chronic stimulant use, counteracting alcohol damage, modulating nitric oxide bidirectionally, repairing peripheral nerve crush injuries, and restoring gut barrier integrity to resolve neuroinflammation-driven depression and anxiety [38]. He confirmed the oral BPC-157 dose doubled from 500mcg to 1000mcg at the same price, and noted that Dr. Predrag Sikirić, who first synthesized BPC-157, reportedly takes 1000mcg every day orally [39]. He ran 1000mcg daily for 45 days in his most recent cycle and called it 'great' [39]. He quoted his own March article on BPC-157, noting the article addresses the cancer concerns by distinguishing between synthetic and natural forms, and arguing most studies tested only 1 of vitamin E's 8 forms in isolation [38], [54]. For a follower with gut inflammation from PPI use, he recommended chewing mastic gum for an hour a day and doing a 45-day cycle of 1000mcg oral BPC-157, saying he'd be 'genuinely surprised if this was not transformational' [55]. He posted a photo with the caption 'titanium dlck inevitable' listing a stack of tadalafil, vesugen, BPC-157, vitamin E, PT-141, red light, and pelvic floor exercises, clarifying it was 'half-meme half-serious' and not for ED [56].
Biohacking Protocols & Foundational Health (~5%): He recommended trying 2 grams of elemental magnesium l-threonate in a day, split doses with food and fiber so you 'don't spend the day shitting your pants.' He called it 'genuinely rejuvenating' [57]. He doubled down on orange juice, stating the world would be a better place if everyone drank a glass of fresh pressed OJ while getting sun in their eyes every morning [58]. When challenged on the sugar content, he fired back that it's 'natural glucose, the primary energy source of the brain' and asked why it's nuts to consume energy in the morning after fasting [59]. He did say to avoid concentrate and 'press it if you must' [59]. He called taking quality vitamin E and drinking orange juice whenever you eat fast food or eat out a 'cheat code to life' that he'll be on until he dies [60]. He also said he believes Coca-Cola is 'good for you' [61]. On thiamine (B1), he said most people reading are likely deficient and could feel more energetic supplementing it, but warned against thiamine mononitrate ('this is for horses') and recommended a better form [62]. For intranasal delivery, he said insulin and selank are his only good experiences, along with CO [63].
Top conversations
6 replies · 2.6k views@basedbiohacker fired back at a user mocking orange juice consumption, arguing that OJ is 'natural glucose, the primary energy source of the brain' and asking why it's nuts to consume energy in the morning after fasting. He clarified to avoid concentrate but defended fresh-pressed OJ as a valid morning energy source [59]. [59]
5 replies · 1.3k views@basedbiohacker argued that anyone calling themselves an 'entrepreneur' is broke and annoying, and that the best answer to 'what do you do' is 'i'm a janitor.' When challenged on the ethics of lying, he explained it's a protective measure against people who want to network or pick your brain once you reach a certain level [32]. [32]
Retweets
62k viewsretweeted @AbudBakri's post defending orange juice as amazing, especially with a shitty meal, arguing that fructose fear-mongering is irrelevant in an isocaloric state, directly quoting David Sinclair's warning against daily OJ. [64]
17.9k viewsretweeted @Helios_Movement's thread on understanding the orexin system before using compounds like modafinil, and how to support it. [65]
16.3k viewsretweeted @RetailGaslight's quote-tweet of @DrJesseMorse defending his peptide prescribing practices, mocking the doctor's tone. [66]
2.4k viewsretweeted @doctormorphh's thread recommending a list of human enhancement accounts to follow, including @BasedBiohacker himself. [67]
779 viewsretweeted @fabianschmid_09's motivational post stating that 'every winner is a loser who tried one more time' and that defeat is psychological. [68]
Calls
- N/AModafinil/ArmodafinilRecommended running 200mg modafinil or 150mg armodafinil every single day for Q4, paired with NAC and agmatine sulfate for tolerance management. [69]
- N/APinealonCalled Pinealon the one peptide bioregulator he'd use for the rest of his life and said he'll be on it until he dies. [10]
- N/AOral BPC-157Recommended a 45-day cycle of 1000mcg oral BPC-157 daily plus mastic gum for gut inflammation from PPI use. [55]
